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Optical Sorting System: Advancing Biomedical Research with AI-Driven Cell Sorting Technology

Beihang University's Optical Sorting System, recognized with the Golden A' Design Award 2025, introduces a transformative solution to the challenges of biological cell sorting in biomedical research. Utilizing advanced optoelectronic dielectrophoresis, microfluidics, and AI-powered nanobiochip technology, the system enables rapid, precise, and non-destructive sorting of tens of thousands of single cells in a single day. This innovation addresses the limitations of traditional hybridoma technology, which often suffers from lengthy cycles, limited diversity, and insufficient functional analysis, thereby accelerating the pace of antibody drug development and reducing associated costs.

The Optical Sorting System operates by preparing and loading biological samples into a microfluidic chip, where optical-induced dielectrophoresis manipulates and sorts cells based on their unique properties. An integrated imaging system captures real-time images, while sophisticated software analyzes and classifies the cells instantly. The sorted cells are then collected and processed for further research, streamlining laboratory workflows and enhancing the reliability of experimental outcomes. This seamless integration of automation, laser technology, and micro-nano fabrication ensures high-throughput, accurate cell sorting with minimal sample damage.

Developed by a dedicated team including Yuanyuan Liu, Hu Yin, Zipeng Zhang, Haocheng Han, and Changgen Li, the Optical Sorting System stands as a testament to Beihang University's commitment to scientific excellence and innovation. The project, completed in Beijing over nearly three years, not only provides a powerful tool for researchers but also sets a new standard for scientific instruments worldwide. The Golden A' Design Award highlights the system's significant impact on advancing art, science, and technology, and its potential to shape the future of biomedical research.

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